LO-7 Chem 153C

Learning Objectives 5

Neurobiochemistry I: Pituitary / Hypothalamus

1. Identify the molecular etiologies of diabetes insipidus.

2. Define the chemistry of ADH/vasopressin and oxytocin, and develop that they are coded for by related genes which also code for their respective neurophysin carriers.

3. Describe how the secretion of ADH/vasopressin and oxytocin is controlled at the physiological and biochemical levels.

4. Discuss the mechanism whereby ADH/vasopressin controls water channels in the cells of the distal convoluted tubules of the kidney.

5. List the actions of oxytocin, including CNS effects, and differentiate how a number of neuromodulator peptides induce a desired behavior which coordinates with their systemic functions.

6. List the hypothalmic releasing and inhibiting factors and explain the biochemical mechanism, including second messengers, in general terms.

7. Diagram the proposed model for the effects of GHRH and somatostatin on adenylate cyclase.

Neurobiochemistry II: Growth Hormone / Prolactin

1 Discuss the close chemical relationship between growth hormone (GH) and prolactin (PRL), as well as between their receptors.

2. List the actions of GH and define which ones are mediated by IGF-I.

3. Compare and contrast IGF-I and insulin, especially with respect to their receptors and how tissues differentially respond to these two similar peptides.

4. Distinguish that the IGF-I receptor is a tyrosine kinase in the insulin receptor family, while the PRL and GH receptors do not posses this activity and must recruit cytoplasmic tyrosine kinases called JAK's.

5. Discuss the tissue specific distribution of GH receptor.

6. Identify the biochemical actions of PRL and its interrelationship to estrogen function.