Fat Metabolism: Overview and Synthesis

1. Identify the names of the pathways associated with fat metabolism.

2. List the tissue associated with the pathways of fat metabolism.

3. Describe the steps and features of lipogenesis including key enzymes, coenzymes, sources of carbons and NADPH and the role of mitochondrial transport.

4. Discuss the key features of the esterification process.

Fat Metabolism: Degradation

1. Describe the pathway for lipolysis and the hormone sensitive lipase reaction.

2. Discuss the role of carnitine in fat degradation.

3. Describe the steps in b-oxidation of fatty acids that produce FADH2 or NADH, and discuss their relationship to energy production.

4. Compare the general features of fatty acid oxidation and biosynthesis.

5. Compare the degradation of odd-chain fatty acids with even chain fatty acids.

6. Identify the principal enzymes in the pathways for ketone body synthesis (ketogenesis) and oxidation.

7. Discuss the general events leading to ketosis and its normal physiologic prevention.

Fat Metabolism: Regulation and Integration

1. Describe how hormone sensitive lipase is regulated.

2 Describe the regulation of acetyl CoA carboxylase.

3. Discuss the coordinated control of fat synthesis and oxidation.

4. Compare energy production for ketones, palmitate and glucose.