Work Sheet 16
DNA Synthesis
1. Define conservative and semiconservative replication.
2. Explain the difference between uni- and bi-directional replication.
3. List the differences and the similarities between leading and lagging strand synthesis.
4. Define the terms primer and template.
5. List the major eukaryotic DNA polymerases and state their function(s).
6. List the cis- and trans- acting factors required for initiating and sustaining DNA replication.
7. Describe how leading and lagging strand synthesis are coordinated.
8. State the function of Telomerase and describe its "probable" mechanism.
9. List some examples of drugs that inhibit replication and explain how they "inhibit" replication.