Work Sheet 7

Myoglobin / Hemoglobin

1. Diagram the basic structural features of myoglobin (Mb) and list the important differences between myoglobin and hemoglobin (Hb).

2. Diagram the iron-heme complex (detailed structure of heme not necessary) and describe how it binds oxygen with the aid of residues in the Mb or Hb protein chain.

3. Discuss the binding of carbon monoxide to the iron-heme complex.

4. Draw a simple oxygen affinity curve for myoglobin, which exists as a monomer.

© Sturm 2014